The ASH Journal Club is a
series that highlights seminal papers in hematology published in Blood and Blood
Advances and features the first author as part of the
engagement. Join us on July 20, 2023, at 12 pm ET to discuss “Endothelial
cell–leukemia interactions remodel drug responses, uncovering T-ALL vulnerabilities” Blood (2023) 141 (5): 503–518. https://doi.org/10.1182/blood.2022015414.
Come learn about how T-ALL patient-derived tumor xenografts
exposed to clinical-stage compounds have drug responses that are mitigated by
endothelial cells (ECs). Also learn
about how co-cultured T-ALL cells and ECs undergo reciprocal transcriptomic changes
linked to bidirectional regulation of multiple pathways and can help identify effective
compounds and therapeutic vulnerabilities.