ASH Journal Club: April 24, 2024, 4:00-5:00 PM Eastern

The ASH Journal Club is a series that highlights seminal papers in hematology published in Blood, Blood Advances, Blood Neoplasia, and Blood Vessels, Thrombosis, & Hemostasis and features a manuscript author as part of the engagement. Join us on April 24^th, 2024 to discuss “Clearance of VWF by hepatic macrophages is critical for the protective effect of ADAMTS13 in sickle cell anemia mice” Blood (2024). Published on March 28, 2024.

DOI: https://doi.org/10.1182/blood.2023021583

Learning Objectives

Please join us for a lively discussion of novel insights uncovered through single-cell RNA sequencing and spatial transcriptomics, shedding light on the distinct transcriptional profiles of hepatic macrophage populations within the sickle cell anemia (SCA) mouse model. Furthermore, we will delve into the pivotal role of efficient Von Willebrand Factor (VWF) clearance by macrophages or Kupffer cells in[DN1] [AB2]  the liver, elucidating the critical protective mechanism of ADAMTS13 in SCA mice.

Presenter:

Lijun Xia, MD, PhD Oklahoma Medical Research Foundation

Moderators:

Deepa Manwani, MD Albert Einstein College of Medicine	Qizhen Shi, MD, PhD Versiti Blood Research Institute