ASH Journal Club: August 28, 2025, 3:00 - 4:00 PM Eastern

Exciting, elegant, and rigorous study showing that vascular dysfunction in sickle cell disease can occur through direct induction of proinflammatory signals in endothelial cells by rigid sickle red blood cells and independently from vaso-occlusion.

Learning Objectives

• Less-deformable sickle red cells marginate toward blood vessel walls, leading to altered local wall shear stress and endothelial dysfunction.
• Pathological biophysical alterations in sickle RBCs cause endothelial dysfunction independently from vaso-occlusion and adhesion.