ASH Journal Club: June 26, 2025, 2:00 - 3:00 PM Eastern

This session will explore the differences in TP53 mutations between classes of myeloid neoplasms; approaches for comparing mutation spectra; and the functional consequences of the mutations and their implications for molecular mechanisms of disease development.

Learning Objectives

• Understand functional differences between types of TP53 disruptions and their potential impacts on myeloid neoplasias.
• Understand the challenges of comparing mutation spectra and some statistical approaches to address these challenges.

Presenter:

Ashwini Jambhekar, PhD Harvard Medical School

Moderators:

Jeremy Baeten, PhD Washington University in Saint Louis	Miriam Kim, MD Washington University in Saint Louis