ASH Journal Club: May 22, 2024, 12:00-1:00 PM Eastern Download Calendar Hold

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The ASH Journal Club is a series that highlights seminal papers in hematology published in Blood, Blood Advances, Blood Neoplasia, and Blood Vessels, Thrombosis, & Hemostasis and features a manuscript author as part of the engagement. Join us on May 22^nd, 2024 to discuss “First-hit SETBP1 mutations cause a myeloproliferative disorder with bone marrow fibrosis” First edition Blood (2024). Published on April 4, 2024.

DOI: https://doi.org/10.1182/blood.2023021349

Learning Objectives

Join us for a discussion on the role of SETBP1 mutations and their role in the pathogenesis of myelofibrosis-like myeloproliferative disorder.  SETBP1 mutations appear in various clonal myeloid disorders, yet their oncogenic potential in leukemia is uncertain, as SETBP1 mutations typically appear as late events during oncogenesis. This article reveals that SETBP1 mutations, acting as a first-hit/early event, drive an aggressive myelofibrosis-like myeloproliferative disorder. Additionally, the authors found that somatic SETBP1 mutations can discriminate between 2 subtypes of triple-negative myelofibrosis, with different genetic landscape and aggressiveness.

Presenter:

Rocco Piazza, MD, PhD San Gerardo Hospital; Monza, Italy

Moderators:

Jonas Jutzi, MD, PhD Brigham and Women’s Hospital	Tania Jain, MD, MBBS Johns Hopkins