Course info
Description
NPM1 mutations are the most common genetic alterations in acute myeloid leukemia (AML) and lead to aberrant cytoplasmic localization of the protein (NPM1c). In this journal club, we examine the proteomic changes associated with NPM1c. By integrating omics datasets from mouse models and samples from patients with data from CRISPR knock-out screens, we explore potential treatment strategies for NPM1-mutant AML.
Learning Objectives
After attending this webinar, participants will be able to:
- Describe how mouse models can be used to investigate disease phenotypes that are difficult to assess directly in humans.
- Describe the major proteomic changes associated with NPM1-mutant AML and how these can be leveraged to design treatment strategies.
- Recognize how integrating multiple omics datasets (e.g., RNA-seq and proteomics) from the same model can reveal interesting transcriptional regulation patterns.
- Explain the workflow from omics data generation to the identification and validation of potential therapeutic vulnerabilities.
Target Audience
- Research trainees interested in learning new hematology research methods
- Acute Myeloid Leukemia researchers of all career levels
- Medical students and those building core hematology knowledge
- Residents and practitioners in primary care requiring hematology fundamentals