Course info
Description
Replication stress exerts an important role in fueling genomic instability characterizing multiple myeloma (MM) evolution and is a cause of drug resistance. Normal and malignant plasma cells are associated with a high transcriptional stress due to the huge production of immunoglobulins. We investigated how transcription-replication conflicts (TRCs), arising from collisions between replication and transcription machineries may represent an Achilles’ heel in MM cells.
Learning Objectives
After attending this webinar, participants will be able to:
- Explain how high-risk patients with MM overexpress genes involved in transcription-replication conflict (TRC) resolution, suggesting they may adapt to replicative and transcriptional stress and benefit from TRC-enhancing therapy.
- Describe how G4 stabilizers could be used to increase TRC and induce toxicity in MM cells.
- Describe how G4 stabilizers synergize with Melphalan, IMiDs, bromodomain and HDAC inhibitors.
Target Audience
- Myeloma researchers of all career levels
- Research trainees interested in learning new hematology research methods
- Research trainees interested in transcription complex biology and regulation
- Medical students and those building core hematology knowledge
Speakers and Moderators
- Moderator: Nisha Joseph, MD, Winship Cancer Institute, Emory University
- Moderator: Lawrence Boise, PhD, Winship Cancer Institute, Emory University
- Presenter: Laure Dutrieux, PhD, Institut Universitaire de France
- Presenter: Jerome Moreaux, PhD, Institut Universitaire de France
Sections
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