802. Chemical Biology and Experimental Therapeutics: Poster II

Gold salt phospholipid inhibits glutathione peroxidase 4 GPx4 and causes cell death in Mantle Cell Lymphoma Demonstration of single agent activity and synergy with ibrutinib

Momelotinib inhibition of JAK STAT in a mouse JAKV617F myelofibrosis model showed concurrent activation of p ERK and p AKT which was reversed by combination therapy using LP 182 a novel MEK PI3K mTOR inhibitor

The transition from myelodysplastic neoplasm to secondary acute myeloid leukemia is revealed by molecular analysis while functional drug screening demonstrates novel sensitivity patterns with clinical implication

The asns inhibitor asx 173 potentiates l asparaginase anticancer activity

Identification of novel potent and selective JAK2V617F inhibitors

Disrupting the PA2G4 NPM1 axis induces nucleolar stress in NPM1c AML

Silver nanoparticles trigger proteotoxicity in multiple myeloma cells via a mechanism distinct from bortezomib and remain efective in BTZ resistant myeloma

Vaccination targeting azacytidine induced neoantigens in the C1498 murine AML model