602. Myeloid Oncogenesis: Basic: Poster III

HMGA1 chromatin regulators drive transcriptional networks governing cell cycle progression immune escape and menin inhibitor resistance in KMT2A r Acute Myeloid Leukemia

Chronic myeloid leukemia CML evolution is not encoded in single cell microstates but emerges from population level macrostates

CD43 functions as a CD47 independent don t eat me signal and novel immune checkpoint in AML

Context dependent recruitment of co factors directs RUNX1 activity in normal and leukemic cells

P2rx7 in AML blasts orchestrates myeloid differentiation through T cell mediated visfatin and lymphotoxin signaling

The long non coding RNA WT1 as controls differentiation programs and leukemic cell fate in AML

Identification of SHMT2 and ADAM28 as potential mediators of NFIC pro growth effects in AML

Transcriptional and splicing dysregulation by U2AF1 mutations contribute to inflammatory and migratory alterations in MDS

Persistent binding of DNMT1 to chromatin causes replication dysfunction in TP53 mutated myeloid neoplasms

Replication fork remodeling is a therapeutic vulnerability in acute myeloid leukemia

Endothelial cell derived mitochondrial transfer to Acute Myeloid Leukemia alters global gene expression to confer chemoresistance

SMARCC1 loss impairs differentiation and enhances self renewal in ASXL1 mutant hematopoietic cells

Boosting anti tumor immunity in NRAS ASXL1 driven Acute Myeloid Leukemia through combined inhibition of MEK and HDACs

Single cell multi omics uncovers differentiation dependent transcriptional programs shaping epigenetic subgroups in AML

Human HSPCs CRISPR engineered to endogenously express oncogenic NRAS generate a transplantable lethal myeloid malignancy targetable with novel RAS therapeutics

FLT3 ITD drives poor prognosis in NPM1 mutated AML via BCAT1 dependent epigenetic regulation

NUP98 rearranged pediatric AML is sustained by a conserved leukemia stem cell program with SPNS2 3 as a targetable vulnerability

Regulation of ribosomal RNA synthesis in Acute Myeloid Leukemia