112. Thalassemia and Globin Gene Regulation: Poster II

Hydroxyurea sequesters the histone methyltransferase G9a at stressed replication forks to reactivate fetal hemoglobin

Ex vivo treatment by mitapivat an allosteric pyruvate kinase activator reduced oxidative stress to support terminal erythropoiesis of non transfusion dependent thalassemia patients due to β thalassemia hb e disease

Evaluating the efficacy and safety of gene therapy in transfusion dependent β thalassemia A focus on hemolysis improvement and clonal hematopoiesis monitoring

High complicated incidence of Gilbert s syndrome in patients with thalassemia Deserve earlier identification and less oversight

Molecular spectrum of alpha thalassemia An unrecognised blood disorder in Nepal