641. Chronic Lymphocytic Leukemia: Basic and Translational: Poster II

Foreign antigen delivered to CLL B cells via membrane IgD leads to a distinct antigen processing pathway that allows antigen specific T cell activation that is superior to membrane IgM delivery

Systematic molecular profiling to identify determinants of response to ibrutinib

Spatial transcriptomic analysis of chronic lymphocytic leukemia lymph nodes reveals tumor microenvironment evolution during disease progression

Loss of cell cycle regulators RB1 and CDKN2A 2B induces CLL with distinct disease kinetics in murine models and shows distinct outcomes in CLL patients

Pirtobrutinib a non covalent BTK inhibitor enhances T cell anti tumor immunity in chronic lymphocytic leukemia CLL

Machine learning based classification of chronic lymphocytic leukemia signalotypes to allows biological and clinical insights into novel CLL subgroups

Acquisition of CLL like epigenetic and transcriptomic states in low count MBL